Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol
- Zang, Qin
- Zhou, Aihua
- Javed, Salim
- Maity, Pradip K.
- Knudtson, Christopher Anton
- Bi, Danse
- Hastings, Jared J.
- Basha, Fatima Z.
- Hanson, Paul R.
Publication date
December 2012
DOI Publisher
Japan Institute of Heterocyclic Chemistry Language
EnglishAbstract
A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, followed by in situ intramolecular thia-Michael addition, was achieved and afforded the titled 1,5,2-dithiazepine-1,1-dioxide scaffolds. Diversification was demonstrated for future library synthesis
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