Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
Hsp90 isoform-selective inhibition is highly desired as it can potentially avoid the toxic side-effe...
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These...
Previously, we reported the Hsp90 inhibitory activity of radamide, an open chain amide chimera of ge...
Dissertation (Ph.D.)--University of Kansas, Medicinal Chemistry, 2007.The 90 kDa heat shock proteins...
Dissertation (Ph.D.)--University of Kansas, Medicinal Chemistry, 2007.The 90 kDa heat shock proteins...
The molecular chaperone HSP90 is currently under investigation as a promising target for anticancer ...
The heat shock protein 90 (Hsp90) family of molecular chaperones is responsible for the conformation...
The heat shock protein 90 (Hsp90) family of molecular chaperones is responsible for the conformation...
This is the author's accepted manuscript. Made available by the permission of the publisher.Several ...
This is the author's accepted manuscript. Made available by the permission of the publisher.Several ...
La résistance aux traitements actuels du cancer (polychimiothérapie) incite à trouver de nouvelles c...
The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting molecular target. D...
Hsp90 isoform-selective inhibition is highly desired as it can potentially avoid the toxic side-effe...
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
Hsp90 isoform-selective inhibition is highly desired as it can potentially avoid the toxic side-effe...
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These...
Previously, we reported the Hsp90 inhibitory activity of radamide, an open chain amide chimera of ge...
Dissertation (Ph.D.)--University of Kansas, Medicinal Chemistry, 2007.The 90 kDa heat shock proteins...
Dissertation (Ph.D.)--University of Kansas, Medicinal Chemistry, 2007.The 90 kDa heat shock proteins...
The molecular chaperone HSP90 is currently under investigation as a promising target for anticancer ...
The heat shock protein 90 (Hsp90) family of molecular chaperones is responsible for the conformation...
The heat shock protein 90 (Hsp90) family of molecular chaperones is responsible for the conformation...
This is the author's accepted manuscript. Made available by the permission of the publisher.Several ...
This is the author's accepted manuscript. Made available by the permission of the publisher.Several ...
La résistance aux traitements actuels du cancer (polychimiothérapie) incite à trouver de nouvelles c...
The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting molecular target. D...
Hsp90 isoform-selective inhibition is highly desired as it can potentially avoid the toxic side-effe...
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
Hsp90 isoform-selective inhibition is highly desired as it can potentially avoid the toxic side-effe...
Resistance to Hsp90 inhibition has become an important concern as several clinical trials are curren...
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