Personalized medicine is emerging in both clinical practice and clinical trials. “Precision” medicine not only promises improved safety and efficacy but also lowered cost in clinical practice and clinical trials. In 2015, President Obama launched the Precision Medicine Initiative. This initiative requires close collaboration among clinicians, researchers, and biostatisticians. Enrichment design is an important strategy for increasing study efficiency in personalized medicine. Enrichment clinical trial designs involve identifying high-risk patients and choosing patients most likely to respond to treatment. In this dissertation, we have developed and applied parametric and non-parametric models to the following specific problems: 1) identifyi...
University of Minnesota Ph.D. dissertation. May 2017. Major: Biostatistics. Advisor: Bradley Carlin....
While safety is the primary objective in Phase I designs of pharmacological or novel treatment devel...
In Phase II oncology trials, targeted therapies are being constantly evaluated for their efficacy in...
Personalized medicine is emerging in both clinical practice and clinical trials. “Precision” medicin...
Numerous human medical problems or diseases have been aided by the development of effective treatmen...
The transition towards personalized medicine is happening and the new experimental framework is rais...
In many study areas, such as epidemiological studies and clinical trials, both enrichment schemes an...
This thesis focuses on the design, statistical operating characteristics and interpretation of early...
Due to the heterogeneity of cancers, the one-size-fits-all treatment approach that works for treatme...
The clinical trial is the most import study for the development of successful novel drugs. The aim o...
Various complex survival models, such as joint models of survival and longitudinal data and multivar...
Randomized trials investigating the efficacy of a single treatment compared to a placebo,quantified ...
My dissertation mainly focus on Bayesian designs for early phase clinical trials with novel target a...
Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-st...
International audienceBackground: Adaptive clinical trials have been increasingly commonly employed ...
University of Minnesota Ph.D. dissertation. May 2017. Major: Biostatistics. Advisor: Bradley Carlin....
While safety is the primary objective in Phase I designs of pharmacological or novel treatment devel...
In Phase II oncology trials, targeted therapies are being constantly evaluated for their efficacy in...
Personalized medicine is emerging in both clinical practice and clinical trials. “Precision” medicin...
Numerous human medical problems or diseases have been aided by the development of effective treatmen...
The transition towards personalized medicine is happening and the new experimental framework is rais...
In many study areas, such as epidemiological studies and clinical trials, both enrichment schemes an...
This thesis focuses on the design, statistical operating characteristics and interpretation of early...
Due to the heterogeneity of cancers, the one-size-fits-all treatment approach that works for treatme...
The clinical trial is the most import study for the development of successful novel drugs. The aim o...
Various complex survival models, such as joint models of survival and longitudinal data and multivar...
Randomized trials investigating the efficacy of a single treatment compared to a placebo,quantified ...
My dissertation mainly focus on Bayesian designs for early phase clinical trials with novel target a...
Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-st...
International audienceBackground: Adaptive clinical trials have been increasingly commonly employed ...
University of Minnesota Ph.D. dissertation. May 2017. Major: Biostatistics. Advisor: Bradley Carlin....
While safety is the primary objective in Phase I designs of pharmacological or novel treatment devel...
In Phase II oncology trials, targeted therapies are being constantly evaluated for their efficacy in...