Parkin belongs to a class of multiple RING domain proteins designated as RBR (RING, in between RING, RING) proteins. In this review we examine what is known regarding the structure/function relationship of the Parkin protein. Parkin contains three RING domains plus a ubiquitin-like domain and an in-between-RING (IBR) domain. RING domains are rich in cysteine amino acids that act as ligands to bind zinc ions. RING domains may interact with DNA or with other proteins and perform a wide range of functions. Some function as E3 ubiquitin ligases, participating in attachment of ubiquitin chains to signal proteasome degradation; however, ubiquitin may be attached for purposes other than proteasome degradation. It was determined that the C-termina...
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Around 10% of PD cases...
Mutations in the parkin gene cause autosomal-recessive juvenile parkinsonism. Parkin encodes a ubiqu...
Mutations in the Parkin gene cause a juvenile-onset for of Parkinson's disease (PD) that is transmit...
Parkin belongs to a class of multiple RING domain proteins designated as RBR (RING, in between RING,...
Missense mutations in park2, encoding the parkin protein, account for approximately 50% of autosomal...
RING-between-RING (RBR) E3 ligases are a class of ubiquitin ligases distinct from RING or HECT E3 li...
Parkin is an E3 ligase that contains a ubiquitin-like (UBL) domain in the N terminus and an R1-in-be...
Parkinson’s disease (PD), the second most common neurodegenerative disease in men. Parkin is an E3 u...
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative str...
In common neurodegenerative diseases among older adults, Parkinson’s disease (PD) ranks the second a...
Parkin is an RBR E3 ubiquitin ligase that is implicated in the development of Parkinson’s Disease. I...
The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encod...
SummaryParkin is an E3 ubiquitin ligase, mutations in which are responsible for autosomal recessive ...
Parkin is an E3 ligase, a ubiquitin writer that ligates single or chains of ubiquitin onto its subst...
Parkin is an RBR E3 ubiquitin ligase that has been implicated in both sporadic and familial Parkinso...
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Around 10% of PD cases...
Mutations in the parkin gene cause autosomal-recessive juvenile parkinsonism. Parkin encodes a ubiqu...
Mutations in the Parkin gene cause a juvenile-onset for of Parkinson's disease (PD) that is transmit...
Parkin belongs to a class of multiple RING domain proteins designated as RBR (RING, in between RING,...
Missense mutations in park2, encoding the parkin protein, account for approximately 50% of autosomal...
RING-between-RING (RBR) E3 ligases are a class of ubiquitin ligases distinct from RING or HECT E3 li...
Parkin is an E3 ligase that contains a ubiquitin-like (UBL) domain in the N terminus and an R1-in-be...
Parkinson’s disease (PD), the second most common neurodegenerative disease in men. Parkin is an E3 u...
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative str...
In common neurodegenerative diseases among older adults, Parkinson’s disease (PD) ranks the second a...
Parkin is an RBR E3 ubiquitin ligase that is implicated in the development of Parkinson’s Disease. I...
The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encod...
SummaryParkin is an E3 ubiquitin ligase, mutations in which are responsible for autosomal recessive ...
Parkin is an E3 ligase, a ubiquitin writer that ligates single or chains of ubiquitin onto its subst...
Parkin is an RBR E3 ubiquitin ligase that has been implicated in both sporadic and familial Parkinso...
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Around 10% of PD cases...
Mutations in the parkin gene cause autosomal-recessive juvenile parkinsonism. Parkin encodes a ubiqu...
Mutations in the Parkin gene cause a juvenile-onset for of Parkinson's disease (PD) that is transmit...