Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical characterization and stability study

International audienceThe phase behavior of the four-component Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex fluids were identified. Non usual W/O microemulsion (L2) as well as hexagonal (H2) liquid-crystal phases were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this complex system