The ototoxic effects of aminoglycoside antibiotics are well known. A mitochondrial mutation (A1555G) is responsible for a maternally inherited hypersensitivity to aminoglycosides causing an antibiotic-induced ototoxicity with non-syndromic hearing loss.The present study reports on the moleculargenetic findings of the deafness-associated mitochondrial A1555G mutation from a German population of 178 children and their relatives in a cohort of 6500 children collected by the German Registry for Hearing Loss in Children (DZH). The diagnosis is made by including anamnestic factors for non-syndromic hearing loss, hearing impaired mother or further female relatives with non-syndromic hearing impairment. Exclusion criteria were e.g. dysmorphism, pre...
ABSTRACT INTRODUCTION: Several mitochondrial DNA mutations have been reported to be associated wit...
The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be ass...
AbstractIntroductionSeveral mitochondrial DNA mutations have been reported to be associated with non...
SummaryIn view of the complex mechanism of hearing, it is not difficult to understand that hearing i...
SummaryThe A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induc...
Despite the risk of permanent ototoxic effects, aminoglycosides remain commonly utilized antibiotics...
Summary: The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-ind...
International audienceOver the last decade a number of distinct mutations in the mitochondrial DNA (...
Mutations in mitochondrial DNA (mtDNA) have been shown to be an important cause of sensorineural hea...
AbstractThe mitochondrial 12S rRNA has been shown to be the hot spot for mutations associated with b...
Hearing impairment is the most prevalent sensorial deficit in the general population. Congenital dea...
Hearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDNA has b...
Hearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDNA has b...
Over the last decade, a number of distinct mutations in the mtDNA (mitochondrial DNA) have been foun...
SummaryHearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDN...
ABSTRACT INTRODUCTION: Several mitochondrial DNA mutations have been reported to be associated wit...
The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be ass...
AbstractIntroductionSeveral mitochondrial DNA mutations have been reported to be associated with non...
SummaryIn view of the complex mechanism of hearing, it is not difficult to understand that hearing i...
SummaryThe A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induc...
Despite the risk of permanent ototoxic effects, aminoglycosides remain commonly utilized antibiotics...
Summary: The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-ind...
International audienceOver the last decade a number of distinct mutations in the mitochondrial DNA (...
Mutations in mitochondrial DNA (mtDNA) have been shown to be an important cause of sensorineural hea...
AbstractThe mitochondrial 12S rRNA has been shown to be the hot spot for mutations associated with b...
Hearing impairment is the most prevalent sensorial deficit in the general population. Congenital dea...
Hearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDNA has b...
Hearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDNA has b...
Over the last decade, a number of distinct mutations in the mtDNA (mitochondrial DNA) have been foun...
SummaryHearing loss involves both genetic and environmental factors. A mutation (A1555G) in the mtDN...
ABSTRACT INTRODUCTION: Several mitochondrial DNA mutations have been reported to be associated wit...
The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be ass...
AbstractIntroductionSeveral mitochondrial DNA mutations have been reported to be associated with non...