Add to ORKGIn CRISPR-based screens for essential genes, Munoz and colleagues and Aguirre and colleagues show that gene-independent targeting of genomic amplifications in human cancer cell lines reduces proliferation or survival. The correlation between CRISPR target site copy number and lethality demonstrates the need for scrutiny and complementary approaches to rule out off-target effects and false positives in CRISPR screens
Large-scale genomic analyses of tumor cells have revealed many genetic alterations present in cancer...
Background: Genome-wide loss-of-function profiling is widely used for systematic identification of g...
The development of targeted therapies has had a significant impact on cancer survival rates. However...
Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viabi...
<div><p>Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-functi...
The CRISPR/Cas9 system has emerged as a disruptive new tool to systematically probe gene function, b...
Abstract Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene es...
Abstract Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the effi...
CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical r...
Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis. We...
Background: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast...
CRISPR-Cas9 provides the means to perform genome editing and facilitates loss-of-function screens. H...
Mutations accumulate in our cells as we age. We hypothesized that CRISPR-Cas9 could genetically kill...
Adaptation of the bacterial CRISPR-Cas9 system to mammalian cells revolutionized the field of functi...
Zhao et al. performed phenotypic CRISPR screens to uncover genes and pathways that suppress DNA dama...
Large-scale genomic analyses of tumor cells have revealed many genetic alterations present in cancer...
Background: Genome-wide loss-of-function profiling is widely used for systematic identification of g...
The development of targeted therapies has had a significant impact on cancer survival rates. However...
Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viabi...
<div><p>Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-functi...
The CRISPR/Cas9 system has emerged as a disruptive new tool to systematically probe gene function, b...
Abstract Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene es...
Abstract Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the effi...
CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical r...
Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis. We...
Background: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast...
CRISPR-Cas9 provides the means to perform genome editing and facilitates loss-of-function screens. H...
Mutations accumulate in our cells as we age. We hypothesized that CRISPR-Cas9 could genetically kill...
Adaptation of the bacterial CRISPR-Cas9 system to mammalian cells revolutionized the field of functi...
Zhao et al. performed phenotypic CRISPR screens to uncover genes and pathways that suppress DNA dama...
Large-scale genomic analyses of tumor cells have revealed many genetic alterations present in cancer...
Background: Genome-wide loss-of-function profiling is widely used for systematic identification of g...
The development of targeted therapies has had a significant impact on cancer survival rates. However...