Heteroatom directed photoarylation of pyridines in the synthesis of Huperzine analogs.

In one synthetic route toward analogs of Huperzine, a natural potent reversible inhibitor of acetylcholinesterase, key heteroatom directed photoarylation reaction is predicted to form the central skeleton in one step from an easily synthesized precursor. Earlier attempts to effect this photoarylation in pyridine systems were not successful. The goal of this project is to develop systems or procedures to successfully effect this key step