Add to ORKGThe purpose of this project was to generate a mouse line containing a heart-specific deletion of genes encoding JNK-1 and -2, which may map to insulin-resistance, to create a model for studying the effects of type II diabetes on cardiomyocytes. The Cre/loxP recombination system was used in a C57BL/6 mouse, with Cre under the control of a MHC promoter to drive expression in cardiomyocytes. PCR analysis showed the creation of 3 Cre-positive mice for JNK1, and 3 for JNK2, providing mice which can be used to determine the potential role of JNK1 and JNK2 in insulin-resistance in heart cells
The purpose of this project was to develop a new product, purified human hormone sensitive lipase (H...
Medulloblastoma (MB) patients suffer a poor prognosis and limitations of current treatments necessit...
This MQP researched transcription factor YY1 in B-cells, which is thought to be a master regulator o...
Type II diabetes is a disorder that affects the body\u27s ability to produce or utilize insulin, and...
Although cardiac natriuretic peptides (NPs) have well characterized roles as vasodilators, recent ev...
Bardet-Biedl Syndrome (BBS) is a pleiotropic ciliopathy characterized by a unique phenotype includin...
This project explores the function of Core Binding Factor (CBF) in B-cell development, and its regul...
Bio Breeding (BB) rats are a well known model for juvenile diabetes. Diabetic prone (DP) and resist...
Multiple sclerosis is an inflammatory disease characterized by damage to neuronal fatty myelin sheat...
A focal adhesion targeting sequence within the protein supervillin regulates the turnover of focal a...
The human gene Suppression of Tumorigenicity-18 (ST-18) encodes a zinc finger protein previously ass...
Heart disease is the number one cause of death in the United States. Despite the prevalence of heart...
MicroRNAs (miRNAs) are non-coding double stranded RNA molecules known to regulate gene expression. T...
Type 1 and Type 2 diabetic patients experience prolonged hyperglycemia punctuated by short episodes ...
The lack of human myocardium for research purposes represents a great problem in studying pathogene...
The purpose of this project was to develop a new product, purified human hormone sensitive lipase (H...
Medulloblastoma (MB) patients suffer a poor prognosis and limitations of current treatments necessit...
This MQP researched transcription factor YY1 in B-cells, which is thought to be a master regulator o...
Type II diabetes is a disorder that affects the body\u27s ability to produce or utilize insulin, and...
Although cardiac natriuretic peptides (NPs) have well characterized roles as vasodilators, recent ev...
Bardet-Biedl Syndrome (BBS) is a pleiotropic ciliopathy characterized by a unique phenotype includin...
This project explores the function of Core Binding Factor (CBF) in B-cell development, and its regul...
Bio Breeding (BB) rats are a well known model for juvenile diabetes. Diabetic prone (DP) and resist...
Multiple sclerosis is an inflammatory disease characterized by damage to neuronal fatty myelin sheat...
A focal adhesion targeting sequence within the protein supervillin regulates the turnover of focal a...
The human gene Suppression of Tumorigenicity-18 (ST-18) encodes a zinc finger protein previously ass...
Heart disease is the number one cause of death in the United States. Despite the prevalence of heart...
MicroRNAs (miRNAs) are non-coding double stranded RNA molecules known to regulate gene expression. T...
Type 1 and Type 2 diabetic patients experience prolonged hyperglycemia punctuated by short episodes ...
The lack of human myocardium for research purposes represents a great problem in studying pathogene...
The purpose of this project was to develop a new product, purified human hormone sensitive lipase (H...
Medulloblastoma (MB) patients suffer a poor prognosis and limitations of current treatments necessit...
This MQP researched transcription factor YY1 in B-cells, which is thought to be a master regulator o...