A Genetic approach to finding new genes in the C. elegans mig-10 signal transduction pathway.

Mutations in the C. elegans gene mig-10 cause defects in neuronal migration, axonal growth, and excretory cell growth. The truncated excretory canal phenotype was used as a genetic model for developmental axonal growth. It was used to isolate mutations in other genes in the mig-10 signal transduction pathway. One new mutation was isolated after two rounds of mutagenesis. Complementation tests and mapping assays showed that neither this mutation, nor several previously isolated mutations, were alleles of mig-10. These mutations may be in genes that act in the same pathway as mig-10