Add to ORKGThe Flinders Sensitive Line (FSL) rat is an animal model of depression, even though it was originally selectively bred for sensitivity to pesticide. In this experiment FSL rats and their counterpart strain Flinders Resistant Line (FRL) rats were evaluated using two behavioral tests, the forced swim test (FST) and the novel object recognition (NOR) test. They were then treated with the tricyclic antidepressant drug desipramine (DMI) for fourteen days and reevaluated. The expected normalization of depressive-like symptoms was seen in the FST; result of the novel object recognition test were inconclusive
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alt...
A Wistar derived inbred line, the WAG/Rij rats, genetically absence epilepsy prone, and their normal...
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential anti...
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive lin...
Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In dev...
Independent depression and fear studies suggest overlap in the brain structures involved in depressi...
Introduction: The Roman low- (RLA) and high-avoidance (RHA) rats were selectively bred for, respecti...
Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment...
A plethora of animal models of depression is described in the literature, aiming at mimicking differ...
Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. ...
Major depressive disorder is a devastating disease characterized by intense and prolonged sadness a...
Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. ...
Background: Major depression with psychotic features presents with severe depressed mood and psychos...
Psychopharmacology (Berl). 2010 Sep;211(4):403-14. Epub 2010 Jun 30. Effects of antidepressants on ...
The forced swim test assesses learned helplessness, which is a feature of depression-like behavior i...
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alt...
A Wistar derived inbred line, the WAG/Rij rats, genetically absence epilepsy prone, and their normal...
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential anti...
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive lin...
Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In dev...
Independent depression and fear studies suggest overlap in the brain structures involved in depressi...
Introduction: The Roman low- (RLA) and high-avoidance (RHA) rats were selectively bred for, respecti...
Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment...
A plethora of animal models of depression is described in the literature, aiming at mimicking differ...
Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. ...
Major depressive disorder is a devastating disease characterized by intense and prolonged sadness a...
Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. ...
Background: Major depression with psychotic features presents with severe depressed mood and psychos...
Psychopharmacology (Berl). 2010 Sep;211(4):403-14. Epub 2010 Jun 30. Effects of antidepressants on ...
The forced swim test assesses learned helplessness, which is a feature of depression-like behavior i...
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alt...
A Wistar derived inbred line, the WAG/Rij rats, genetically absence epilepsy prone, and their normal...
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential anti...