Methylation of O6-methylguanine-DNA methyltransferase (MGMT) has been extensively studied as a biomarker in predicting the prognosis of patients with GBM (Glioblastoma multiforme). Its significance has been studied in various subgroups, including age, gender and even race. Correlation between prognosis with MGMT methylation and different treatment regimens has also been studied in detail. There are multiple techniques to analyze MGMT methylation in tumour specimen. We review the current evidence for the importance of MGMT methylation as a biomarker for prognosis in GBM patients, the techniques to analyze it and the effect of epidemiologic factors on its significance
Methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter is predictive for treatm...
O⁶-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potentia...
The DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT) antagonizes the genotoxic effec...
Abstract Background Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene ...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of nove...
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a universally poor prognos...
OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MG...
Background: The standard of care for glioblastoma is concurrent chemoradiotherapy and adjuvant chemo...
O6-methylguanine-DNA-methyltransferase (MGMT) has emerged as a relevant predictor of therapeutic res...
BACKGROUND: Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emer...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of nove...
Background: Glioblastoma Multiforme (GBM) is the highest-mortality tumor of the central nervous syst...
Patients with non-resectable glioblastoma generally exhibit a poor prognosis, even after radiotherap...
Current treatment options for diffuse glioma patients include maximum safe resection followed by a c...
Abstract BACKGROUND Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene ...
Methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter is predictive for treatm...
O⁶-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potentia...
The DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT) antagonizes the genotoxic effec...
Abstract Background Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene ...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of nove...
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a universally poor prognos...
OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MG...
Background: The standard of care for glioblastoma is concurrent chemoradiotherapy and adjuvant chemo...
O6-methylguanine-DNA-methyltransferase (MGMT) has emerged as a relevant predictor of therapeutic res...
BACKGROUND: Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emer...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of nove...
Background: Glioblastoma Multiforme (GBM) is the highest-mortality tumor of the central nervous syst...
Patients with non-resectable glioblastoma generally exhibit a poor prognosis, even after radiotherap...
Current treatment options for diffuse glioma patients include maximum safe resection followed by a c...
Abstract BACKGROUND Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene ...
Methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter is predictive for treatm...
O⁶-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potentia...
The DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT) antagonizes the genotoxic effec...
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