Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer
- Lapadula, Walter Jesús
- Marcet, Paula Lorena
- Mascotti, María Laura
- Sánchez Puerta, María Virginia
- Juri Ayub, Maximiliano
DOIAbstract
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and their presence has also been confirmed in several bacterial species. Recently, we reported for the first time in silico evidence of RIP encoding genes in metazoans, in two closely related species of insects: Aedes aegypti and Culex quinquefasciatus. Here, we have experimentally confirmed the presence of these genes in mosquitoes and attempted to unveil their evolutionary history. A detailed study was conducted, including evaluation of taxonomic distribution, phylogenetic inferences and microsynteny analyses, indicating that mosquito RIP g...
Add to ORKG