A Single Administration of the GnRH Antagonist Acyline Inhibits Basal and GnRH-Stimulated Serum Testosterone Concentrations in Male Dogs
- Garcia Romero, Guadalupe
- Mattioli, Guillermo Alberto
- Rosa, Diana Esther
- Díaz, Jorge Daniel
- Abeyá, María Mercedes
- Gobello, María Cristina
DOIAbstract
The objective of this study was to describe testosterone (T) response to GnRH challenge in antagonist-treated dogs over a 30-day period. Eight mongrel dogs were randomly assigned to either the GnRH antagonist acyline 330μg/kg sc (ACY; n=4) or a placebo group (PLA; n=4). The dogs were serially challenged with the GnRH agonist, buserelin 0.2μg/kg sc on days -1, 1, 3, 7, 10, 14, 21 and 30. On these days, blood samples for T determinations were collected before (-30min) and 60, 120 and 180min after the agonist injection. Basal (-30min) and post-GnRH agonist stimulation T values were compared by anova for repeated measures. Before treatments (day -1), there were no differences in basal T serum concentrations between groups (p>0.1). After treatme...
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