ApoE ɛ4 genotype and the age at onset of temporal lobe epilepsy: A case-control study and meta-analysis.
- Kauffman, Marcelo Andres
- Consalvo, Damian
- González Morón, Dolores
- Lereis, Virginia Pujol
- Kochen, Sara Silvia
DOIAbstract
In order to investigate the role of ApoE e{open}4 as a modifier of the age at onset of temporal lobe epilepsy (TLE), we performed a molecular epidemiology study in 78 patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Genotyping was done by a PCR-RFLP assay. In order to better estimate the role of this variant as a modifier of the age at onset, we also performed a systematic review of the literature. We included our results into a meta-analysis along with data available from seven published studies with 728 patients that looked into the role of ApoE e{open}4 in TLE. We found that ApoE e{open}4 carriers in our population had a non-significant earlier age of epilepsy onset than non-carriers. The meta-analysis confirmed thi...
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