Single nucleotide polymorphisms may explain the contrasting phenotypes of two variants of a multidrug-resistant Mycobacterium tuberculosis strain
- Bigi, Maria de Las Mercedes
- Lopez, Beatriz
- Blanco, Federico Carlos
- Sasiain, María del Carmen
- de la Barrera, Silvia Susana
- Marti, Marcelo Adrian
- Sosa, Ezequiel
- Fernández Do Porto, Darío Augusto
- Ritacco, Gloria Viviana
- Bigi, Fabiana
- Soria, Marcelo Abel
DOIAbstract
Globally, about 4.5% of new tuberculosis (TB) cases are multi-drug-resistant (MDR), i.e. resistant to the two most powerful first-line anti-TB drugs. Indeed, 480,000 people developed MDR-TB in 2015 and 190,000 people died because of MDR-TB. The MDR Mycobacterium tuberculosis M family, which belongs to the Haarlem lineage, is highly prosperous in Argentina and capable of building up further drug resistance without impairing its ability to spread. In this study, we sequenced the whole genomes of a highly prosperous M-family strain (Mp) and its contemporary variant, strain 410, which produced only one recorded tuberculosis case in the last two decades. Previous reports have demonstrated that Mp induced dysfunctional CD8+ cytotoxic T cell activ...
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