Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance

Nuclear magnetic resonance is a powerful tool for probing the structures of chemical and biological systems. Combined with field gradients it leads to NMR imaging (MRI), a widespread tool in non-invasive examinations. Sensitivity usually limits MRI's spatial resolution to tens of micrometers, but other sources of information like those delivered by constrained diffusion processes, enable one extract morphological information down to micron and sub-micron scales. We report here on a new method that also exploits diffusion-isotropic or anisotropic-to sense morphological parameters in the nm-mm range, based on distributions of susceptibility-induced magnetic field gradients. A theoretical framework is developed to define this source of information, leading to the proposition of internal gradient-distribution tensors. Gradient-based spin-echo sequences are designed to measure these new observables. These methods can be used to map orientations even when dealing with unconstrained diffusion, as is here demonstrated with studies of structured systems, including tissues.Fil: Alvarez, Gonzalo Agustin. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Weizmann Institute Of Science Israel; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Shemesh, Noam. Champalimaud Neuroscience Programme At The Champalimaud Centre For The Unknown; Portugal. Weizmann Institute Of Science Israel; IsraelFil: Frydman, Lucio. Weizmann Institute Of Science Israel; Israe