Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
- Castrogiovanni, Daniel Cayetano
- Alzamendi, Ana
- Ongaro Gambino, Luisina
- Giovambattista, Andres
- Gaillard, Rolf C.
- Spinedi, Eduardo Julio
DOIAbstract
The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rat...
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