The role of hyaluronan as a drug carrier to enhance the bioavailability of extended release ophthalmic formulations. Hyaluronan-timolol ionic complexes as a model case
- Battistini, Franco David
- Tartara, Luis Ignacio
- Boiero, Carolina
- Guzman, Maria Laura
- Luciani Giacobbe, Laura Carolina
- Palma, Santiago Daniel
- Allemandi, Daniel Alberto
- Manzo, Ruben Hilario
- Olivera, Maria Eugenia
DOIAbstract
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect. Dispersions of a complex of 0.5% w/v of sodium hyaluronate (HyNa) loaded with 0.5% w/v of timolol maleate (TM) were obtained and presented a counterionic condensation higher than 75%. For comparison a similar complex obtained with hyaluronic acid (HyH) was also prepared. Although the viscosity of HyNa-TM was significantly higher than that of HyH-TM, in vitro release of TM from both complexes showed a similar extended drug release profile (20–31% over 5 h) controlled by diffusion and ionic exchan...
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