An alternative approach toward 2-aryl-2H-pyrazolo[4,3-c]-quinolin-3-ones by a multistep synthesis

Lopez Rivilli, Marisa Juana
Moyano, Elizabeth Laura
Yranzo, Gloria Inés

Open link

Publication date

January 2010

DOI

10.1016/j.tetlet.2009.10.123

Publisher

Elsevier BV

Journal

Tetrahedron Letters

Abstract

A series of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones derivatives 6 and 7 was conveniently prepared. A multistep synthesis was carried out starting from dichloro- and bromoanilines (1a-b) and diethyl 2-(ethoxymethylene)malonate using a slightly modified Gould-Jacobs reaction. In this work we present a novel chlorination strategy to prepare quinoline derivatives 4 in excellent yields as key intermediates in the synthesis of the target compounds. Several reaction conditions were evaluated to optimize the formation of pyrazoloquinolinone nucleus. Differences in chemical behavior of both chloroquinolinones 4a-b with aryl and benzyl-hydrazines are also discussed.Fil: Lopez Rivilli, Marisa Juana. Consejo Nacional de Investigaciones Científicas y T...

Extracted data

We use cookies to provide a better user experience.

Data Protection

An alternative approach toward 2-aryl-2H-pyrazolo[4,3-c]-quinolin-3-ones by a multistep synthesis

Abstract

Extracted data

An alternative approach toward 2-aryl-2H-pyrazolo[4,3-c]-quinolin-3-ones by a multistep synthesis

Abstract

Extracted data

Related items

Related items