The immunological effect of hyaluronan in tumor angiogenesis
- Spinelli, Fiorella Mercedes
- Vitale, Daiana Luján
- Demarchi, Gianina
- Cristina, Silvia Carolina
- Alaniz, Laura Daniela
DOIAbstract
The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review,...
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