Elevated serum levels of free interleukin-18 in adult-onset Still's disease
- Girard, Charlotte
- Rech, Jürgen
- Brown, Michael
- Allali, Danièle
- Roux-Lombard, Pascale
- Spertini, François
- Schiffrin, Eduardo J
- Schett, Georg
- Manger, Bernhard
- Bas, Sylvette
- Del Val, Greg
- Gabay, Cem
DOIAbstract
IL-18 is a pro-inflammatory cytokine of the IL-1 family that is naturally inhibited by IL-18 binding protein (IL-18BP). High levels of IL-18 have been described in the serum of adult-onset Still's disease (AOSD) patients, but only total IL-18 levels (including inactive IL-18 bound to IL-18BP) have been measured. With a specific immunoassay, we aimed to measure free IL-18 serum levels in AOSD patients and other rheumatic diseases
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