Retinoic acid inducible gene (RIG-I)-mediated innate immunity plays a pivotal role in defence against virus infections. Previously we have shown that Sendai virus (SeV) defective interfering (DI) RNA functions as an exclusive and potent RIG-I ligand in DI-RNA-rich SeV-Cantell infected cells. To further understand how RIG-I is activated during SeV infection, we used a different interferon (IFN)-inducing SeV strain, recombinant SeVΔC, which, in contrast to SeV-Cantell is believed to stimulate IFN production due to the lack of the SeV IFN antagonist protein C. Surprisingly, we found that in SevΔC-infected cells, DI RNAs also functioned as an exclusive RIG-I ligand. Infections with wild-type SeV failed to generate any RIG-I-associated immunosti...
Sendai virus infection strongly induces interferon (IFN) production and has recently been shown to i...
RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses ...
Abstract Background Retinoic acid-inducible gene I (RIG-I) is a key cytosolic receptor of the innate...
The Cantell strain of Sendai virus (SeV-C) represents a typical laboratory attenuated virus which is...
Sendai virus (SeV) infection of interferon (IFN)-competent cells is one of the most efficient ways o...
One of the accessory proteins of Sendai virus (SeV), C, translated from an alternate reading frame o...
As infection with wild-type (wt) Sendai virus (SeV) normally activates beta interferon (IFN-beta) ve...
We have studied the relationship between the Sendai virus (SeV) C proteins (a nested set of four pro...
The Sendai virus (SeV) C gene codes for a nested set of four C proteins that carry out several funct...
One of the accessory proteins of Sendai virus (SeV), C, translated from an alternate reading frame o...
The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be assoc...
Sendai virus (SeV) infection causes the transcriptional induction of many cellular genes that are al...
AbstractSendai virus (SeV) renders cells unresponsive to interferon (IFN)-α. To identify viral facto...
The Sendai virus (SeV) C proteins are known to interact with Stat1 to prevent interferon (IFN)-induc...
ABSTRACT Stimulation of the antiviral response depends on the sensing of viral pathogen-associated m...
Sendai virus infection strongly induces interferon (IFN) production and has recently been shown to i...
RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses ...
Abstract Background Retinoic acid-inducible gene I (RIG-I) is a key cytosolic receptor of the innate...
The Cantell strain of Sendai virus (SeV-C) represents a typical laboratory attenuated virus which is...
Sendai virus (SeV) infection of interferon (IFN)-competent cells is one of the most efficient ways o...
One of the accessory proteins of Sendai virus (SeV), C, translated from an alternate reading frame o...
As infection with wild-type (wt) Sendai virus (SeV) normally activates beta interferon (IFN-beta) ve...
We have studied the relationship between the Sendai virus (SeV) C proteins (a nested set of four pro...
The Sendai virus (SeV) C gene codes for a nested set of four C proteins that carry out several funct...
One of the accessory proteins of Sendai virus (SeV), C, translated from an alternate reading frame o...
The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be assoc...
Sendai virus (SeV) infection causes the transcriptional induction of many cellular genes that are al...
AbstractSendai virus (SeV) renders cells unresponsive to interferon (IFN)-α. To identify viral facto...
The Sendai virus (SeV) C proteins are known to interact with Stat1 to prevent interferon (IFN)-induc...
ABSTRACT Stimulation of the antiviral response depends on the sensing of viral pathogen-associated m...
Sendai virus infection strongly induces interferon (IFN) production and has recently been shown to i...
RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses ...
Abstract Background Retinoic acid-inducible gene I (RIG-I) is a key cytosolic receptor of the innate...