Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques
- Duran-Struuck, Raimon
- Sondermeijer, Hugo P
- Buehler, Leo Hans
- Alonso-Guallart, Paula
- Zitsman, Jonah
- Kato, Yojiro
- Wu, Anette
- McMurchy, Alicia N
- Woodland, David
- Griesemer, Adam
- Martinez, Mercedes
- Boskovic, Svetlan
- Kawai, Tatsuo
- Cosimi, A Benedict
- Wuu, Cheng-Shie
- Slate, Andrea
- Mapara, Markus
- Baker, Sam
- Tokarz, Rafal
- Dʼ Agati, Vivette
- Hammer, Scott
- Pereira, Marcus
- Lipkin, W Ian
- Wekerle, Thomas
- Levings, Megan
- Sykes, Megan
Publication date
January 2017
DOI Publisher
Ovid Technologies (Wolters Kluwer Health) ISSN
0041-1337 Citation count (estimate)
16Abstract
Infusion of recipient regulatory T cells (Treg) promotes durable mixed hematopoietic chimerism and allograft tolerance in mice receiving allogeneic BMT with minimal conditioning. We applied this strategy in a Cynomolgus macaque model
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