The pancreas is an organ composed of the exocrine and endocrine glands. The exocrine gland consists of acinar cells and duct cells responsible for digestion of protein, nucleic acids and lipids. The endocrine compartment is formed of islets of Langerhans, cell clusters, in which five cell types are present: glucagon producing alpha cells, insulin producing beta cells, somatostatin producing delta cells, pancreatic polypeptide producing PP cells and ghrelin producing epsilon cells (not present in adult mice). These hormone-producing endocrine cells play a major role in regulating the glucose metabolism. In diabetes mellitus type I and II, there is a dysregulation of the function and or loss of beta cells which result in hyperglycemia (high l...
Diabetes mellitus is amongst the leading causes of morbidity and mortality worldwide. Insulin-produc...
SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the ...
ABSTRACT: Regeneration of insulin-producing β-cells from resident pancreas progenitors requires an u...
The pancreas is composed of two compartments that deliver digestive enzymes and endocrine hormones t...
In this Special Issue of the Int. J. Dev. Biol., we summarize our own studies on the development of ...
Conditional gene deletion in specific cell populations has helped the understanding of pancreas deve...
Porciuncula, Angelo et al.Efficient induction of defined lineages in pluripotent stem cells constitu...
Considerable knowledge of the ontogeny of the endocrine pancreas has been gained in recent years, ma...
SummaryPancreatic β cells are of great interest for the treatment of type 1 diabetes. A number of st...
GPR120-IRES-EGFP mice were generated on C57BL/6J background. The sequence of IRES-EGFP was inserted ...
Human pluripotent stem cells (PSCs) provide a powerful model system for the study of early human dev...
Ontogenic relationships between the different endocrine cell types of the islets of Langerhans were ...
Aims/hypothesis: The aim of the study was to investigate the potential of human pancreatic non-endoc...
Aims/hypothesis Therapeutic cloning has been reported to have potential in the treatment of several ...
Although mouse models have represented a major tool for understanding and predicting molecular mecha...
Diabetes mellitus is amongst the leading causes of morbidity and mortality worldwide. Insulin-produc...
SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the ...
ABSTRACT: Regeneration of insulin-producing β-cells from resident pancreas progenitors requires an u...
The pancreas is composed of two compartments that deliver digestive enzymes and endocrine hormones t...
In this Special Issue of the Int. J. Dev. Biol., we summarize our own studies on the development of ...
Conditional gene deletion in specific cell populations has helped the understanding of pancreas deve...
Porciuncula, Angelo et al.Efficient induction of defined lineages in pluripotent stem cells constitu...
Considerable knowledge of the ontogeny of the endocrine pancreas has been gained in recent years, ma...
SummaryPancreatic β cells are of great interest for the treatment of type 1 diabetes. A number of st...
GPR120-IRES-EGFP mice were generated on C57BL/6J background. The sequence of IRES-EGFP was inserted ...
Human pluripotent stem cells (PSCs) provide a powerful model system for the study of early human dev...
Ontogenic relationships between the different endocrine cell types of the islets of Langerhans were ...
Aims/hypothesis: The aim of the study was to investigate the potential of human pancreatic non-endoc...
Aims/hypothesis Therapeutic cloning has been reported to have potential in the treatment of several ...
Although mouse models have represented a major tool for understanding and predicting molecular mecha...
Diabetes mellitus is amongst the leading causes of morbidity and mortality worldwide. Insulin-produc...
SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the ...
ABSTRACT: Regeneration of insulin-producing β-cells from resident pancreas progenitors requires an u...