Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction
- Wei, Fang-Fei
- Trenson, Sander
- Monney, Pierre
- Yang, Wen-Yi
- Pruijm, Menno
- Zhang, Zhen-Yu
- Bouatou, Yassine
- Huang, Qi-Fang
- Ponte, Belen
- Martin, Pierre-Yves
- Thijs, Lutgarde
- Kuznetsova, Tatiana
- Allegaert, Karel
- Janssens, Stefan
- Vermeer, Cees
- Verhamme, Peter
- Burnier, Michel
- Bochud, Murielle
- Ehret, Georg Benedikt
- Staessen, Jan A
Publication date
January 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium
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