Reactive oxygen species in skeletal muscle cells: detection, modulation and implication in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a X-linked genetic disease that affects 1/3500 boy. [1][2][3] It is caused by a mutation in the gene that codes for the dystrophin located on the chromosome X which leads to the absence of this protein in the affected organism. Dystrophin has a major importance in muscle cells and its absence leads to eventual muscle weakness and fragility.[2][3] The disease is characterized by progressive damage including necrosis, inflammation and fibrosis