Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis
- Disanto, Giulio
- Barro, Christian
- Benkert, Pascal
- Naegelin, Yvonne
- Schädelin, Sabine
- Giardiello, Antonella
- Zecca, Chiara
- Blennow, Kaj
- Zetterberg, Henrik
- Leppert, David
- Kappos, Ludwig
- Gobbi, Claudio
- Kuhle, Jens
- Lalive d'Epinay, Patrice
- Swiss Multiple Sclerosis Cohort Study Group
DOIAbstract
Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS)
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