Background and aims Opioid formulations with properties to deter abuse (abuse‐deterrent formulations; ADFs) have been developed as one response to the prescription opioid \u27epidemic\u27. As for all medicines, ADFs undergo evaluation of safety and efficacy prior to registration for marketing. However, reduced extra‐medical use (the primary intended outcome of ADFs and reason for their introduction) can only be established in post‐marketing observational studies, comparing them to opioid formulations without abuse‐deterrent properties. This has implications for various features of study design and analysis. We discuss proposals for the design, conduct, governance and reporting of post‐marketing studies on the effectiveness of pharmaceutical...
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article dis...
Prescription opioid abuse in the United States is an alarming health issue. In 2015, approximately 2...
<p><b>Objective:</b> Prescription opioid misuse and abuse is a serious public health concern that ca...
Background and aims:Opioid formulations with properties to deter abuse (abuse‐deterrent formulations...
BACKGROUND AND AIMS: Opioid formulations with properties to deter abuse (abuse-deterrent formulation...
Introduction It has been argued that tapentadol may pharmacologically have lower abuse potential tha...
Opioids are essential to the management of pain in many patients, but they also are associated with ...
Background: Evaluation of tamper resistant formulations (TRFs) and classwide Risk Evaluation and Mit...
Research Objective: To inform factors influencing the prescribing and dispensing of abuse-deterrent ...
Background: Recent increases in the nonmedical use of pharmaceutical opioids and the adverse outcome...
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See ...
Objective: Evaluate beliefs and behaviors pertaining to abuse-deterrent opioids (ADFs). Design: Sur...
Background: In drug studies, research designs requiring no prior exposure to certain drug classes ma...
Background: Over the past decade, U.S. FDA has approved 10 opioid analgesics in abuse-deterrent form...
The US Food and Drug Administration (FDA) is encouraging the innovation of long-acting opioid formul...
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article dis...
Prescription opioid abuse in the United States is an alarming health issue. In 2015, approximately 2...
<p><b>Objective:</b> Prescription opioid misuse and abuse is a serious public health concern that ca...
Background and aims:Opioid formulations with properties to deter abuse (abuse‐deterrent formulations...
BACKGROUND AND AIMS: Opioid formulations with properties to deter abuse (abuse-deterrent formulation...
Introduction It has been argued that tapentadol may pharmacologically have lower abuse potential tha...
Opioids are essential to the management of pain in many patients, but they also are associated with ...
Background: Evaluation of tamper resistant formulations (TRFs) and classwide Risk Evaluation and Mit...
Research Objective: To inform factors influencing the prescribing and dispensing of abuse-deterrent ...
Background: Recent increases in the nonmedical use of pharmaceutical opioids and the adverse outcome...
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See ...
Objective: Evaluate beliefs and behaviors pertaining to abuse-deterrent opioids (ADFs). Design: Sur...
Background: In drug studies, research designs requiring no prior exposure to certain drug classes ma...
Background: Over the past decade, U.S. FDA has approved 10 opioid analgesics in abuse-deterrent form...
The US Food and Drug Administration (FDA) is encouraging the innovation of long-acting opioid formul...
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article dis...
Prescription opioid abuse in the United States is an alarming health issue. In 2015, approximately 2...
<p><b>Objective:</b> Prescription opioid misuse and abuse is a serious public health concern that ca...