Add to ORKGIt is with great interest we have read the article GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1 (Zhou et al., 2018). Interestingly, this study showed that GLYX-13 prevents hippocampal N-methyl-D-aspartate receptor subtype 2B-Disrupted in schizophrenia 1 (GluN2B-DISC1) signaling and behavioural changes induced by schizophrenia-mimetic drug MK801 in mice. To confirm GluN2B directly regulating DISC1, these researchers showed that the effects of GLYX-13 were vanished after GluN2B knockdown in mice
Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. D...
SummaryCurrent antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction wit...
The pathophysiology of schizophrenia may involve reduced NMDA receptor function and experimental mod...
Background: Evidence supports that the hypofunction of N-methyl-D-aspartate receptor (NMDAR) and dow...
<p>Background: Evidence supports that the hypofunction of N-methyl-D-aspartate receptor (NMDAR) and ...
© 2020 by the author.N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP), d...
Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is simi...
Background: The pathogenesis of schizophrenia has been linked to N-methyl-D-aspartate receptor (NMDA...
It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-posit...
Schizophrenia is a debilitating mental disorder, affecting more than 30 million people worldwide. As...
The N-methyl-D aspartate receptors (NMDARs) are ligand-gated ion channels, which play important role...
Schizophrenia is a devastating disorder thought to evolve from a combination of environmental and ge...
Multiple neurotransmitter systems have been implicated in the pathophysiology of schizophrenia. In p...
Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy i...
Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positiv...
Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. D...
SummaryCurrent antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction wit...
The pathophysiology of schizophrenia may involve reduced NMDA receptor function and experimental mod...
Background: Evidence supports that the hypofunction of N-methyl-D-aspartate receptor (NMDAR) and dow...
<p>Background: Evidence supports that the hypofunction of N-methyl-D-aspartate receptor (NMDAR) and ...
© 2020 by the author.N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP), d...
Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is simi...
Background: The pathogenesis of schizophrenia has been linked to N-methyl-D-aspartate receptor (NMDA...
It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-posit...
Schizophrenia is a debilitating mental disorder, affecting more than 30 million people worldwide. As...
The N-methyl-D aspartate receptors (NMDARs) are ligand-gated ion channels, which play important role...
Schizophrenia is a devastating disorder thought to evolve from a combination of environmental and ge...
Multiple neurotransmitter systems have been implicated in the pathophysiology of schizophrenia. In p...
Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy i...
Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positiv...
Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. D...
SummaryCurrent antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction wit...
The pathophysiology of schizophrenia may involve reduced NMDA receptor function and experimental mod...