Pre-pregnancy dietary patterns and risk of gestational diabetes mellitus: results from an Australian population-based prospective cohort study

Aims/hypothesis: We examined the associations between pre-pregnancy dietary patterns and the incidence of gestational diabetes mellitus (GDM) in a population-based cohort study of women of reproductive age. Methods: The Australian Longitudinal Study on Women\u27s Health included 3,853 women without pre-existing diabetes who were followed-up between 2003 and 2012. Pre-pregnancy dietary patterns were derived using factor analysis based on 101 food items from a validated food frequency questionnaire. GDM was self-reported and validated in a subsample. Multivariable regression models with generalised estimating equations were used to estimate RR and 95% CI. Results: During 9 years follow-up, 292 GDM cases (4.4%) were documented in 6,626 pregnancies. No associations were found for the \u27Fruit and low-fat dairy\u27 and \u27Cooked vegetables\u27 patterns. The \u27Meats, snacks and sweets\u27 pattern was associated with higher GDM risk after adjustment for socioeconomic, reproductive and lifestyle factors (RR [95% CI] per SD increase in score: 1.38 [1.02, 1.86]). Further adjustment for BMI attenuated the results (1.35 [0.98, 1.81]). In stratified analysis, the \u27Meats, snacks and sweets\u27 pattern was associated with significantly higher GDM risk in parous and obese women, and in women with lower educational qualifications. The \u27Mediterranean-style\u27 pattern was associated with lower GDM risk in the fully adjusted model (0.85 [0.76, 0.98]). Conclusions/interpretation: These findings support general dietary recommendations for women of reproductive age to consume a diet rich in vegetables, whole grains, nuts and fish, and low in red and processed meats and snacks. Further prospective studies are needed to confirm these findings