The pleiotropic biologic effects of interferon (IFN) are mediated through regulation of the expression of numerous IFN-sensitive genes. Peripheral blood mononuclear cells (PBMCs) obtained from healthy donors were analyzed to study the immunoregulatory and antiviral messenger RNAs (mRNAs) and proteins regulated by pegylated IFN-α2b (PEG-IFN-α2b) and IFN-α2b. A dose-dependent and time-dependent response for multiple IFN-regulated genes was observed. IFN-dependent protein production and secretion were correlated with IFN-regulated mRNA induction. Overall regulation of gene expression patterns for PEG-IFN-α2b and IFN-α2b was comparable, even though the antiviral activity of PEG-IFN-α2b demonstrated a longer biologic halflife in vitro compared w...
Abstract Virus infection induces the production of type I interferons (IFNs). IFNs bind to their het...
Interferon (IFN)-alpha receptor mRNA expression in liver of patients with chronic hepatitis C has be...
Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins...
Interferon alfa (IFN-) is an approved therapeutic agent for chronic hepatitis C. To directly charact...
Interferons are key modulators of the immune system, and are central to the control of many diseases...
The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α for the treat...
grantor: University of TorontoThe biology of interferon-alpha (IFN-$\alpha$) proteins has ...
grantor: University of TorontoThe biology of interferon-alpha (IFN-$\alpha$) proteins has ...
<div><p>The levels of expression of interferon-stimulated genes (ISGs) in liver are associated with ...
Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on...
Interferons are key modulators of the immune system, and are central to the control of many diseases...
Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on...
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early ...
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early ...
The relative activities of interferon-α2b (IFN-α2b) and polyethylene glycol12000–IFN-α2b (PEG–IFN-α2...
Abstract Virus infection induces the production of type I interferons (IFNs). IFNs bind to their het...
Interferon (IFN)-alpha receptor mRNA expression in liver of patients with chronic hepatitis C has be...
Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins...
Interferon alfa (IFN-) is an approved therapeutic agent for chronic hepatitis C. To directly charact...
Interferons are key modulators of the immune system, and are central to the control of many diseases...
The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α for the treat...
grantor: University of TorontoThe biology of interferon-alpha (IFN-$\alpha$) proteins has ...
grantor: University of TorontoThe biology of interferon-alpha (IFN-$\alpha$) proteins has ...
<div><p>The levels of expression of interferon-stimulated genes (ISGs) in liver are associated with ...
Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on...
Interferons are key modulators of the immune system, and are central to the control of many diseases...
Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on...
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early ...
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early ...
The relative activities of interferon-α2b (IFN-α2b) and polyethylene glycol12000–IFN-α2b (PEG–IFN-α2...
Abstract Virus infection induces the production of type I interferons (IFNs). IFNs bind to their het...
Interferon (IFN)-alpha receptor mRNA expression in liver of patients with chronic hepatitis C has be...
Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins...