Add to ORKGSpontaneous covalent assembly of short RNA fragments has been proposed as a plausible prebiotically relevant pathway to a self‐reproducing system. We previously showed that the Azoarcus group I intron could self‐assemble from four RNA fragments. Here, we extended this fragmentation to five RNAs that averaged \u3c40 nucleotides in length. We optimized this reaction and showed that a dehydration–rehydration sequence was the most effective means to date to shift the self‐assembly equilibrium from reactants to products
An early stage of life likely used catalytic RNAs (ribozymes) to support self-replication and a meta...
The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme th...
The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as geno...
SummaryThe Azoarcus group I ribozyme was broken into four fragments, 39–63 nucleotides long, that ca...
The question about the origins of life often appears as a difficult question to answer. A more relia...
The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model ...
The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model ...
Origins-of-life research requires searching for a plausible transition from simple chemicals to larg...
SummaryPrebiotic chemical reactions would have been greatly aided by a process whereby living materi...
This research demonstrates chemical reactions of RNA molecules that allow them to increase in length...
AbstractRNA strand exchange through phosphor-nucleotidyl transfer reactions is an intrinsic chemistr...
Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyz...
Understanding the mechanism of spontaneous formation of ribonucleotides under realistic prebiotic co...
AbstractWe have engineered a self-processing RNA, derived from the hairpin ribozyme that runs throug...
International audienceUnderstanding the mechanism of spontaneous formation of ribonucleotides under ...
An early stage of life likely used catalytic RNAs (ribozymes) to support self-replication and a meta...
The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme th...
The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as geno...
SummaryThe Azoarcus group I ribozyme was broken into four fragments, 39–63 nucleotides long, that ca...
The question about the origins of life often appears as a difficult question to answer. A more relia...
The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model ...
The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model ...
Origins-of-life research requires searching for a plausible transition from simple chemicals to larg...
SummaryPrebiotic chemical reactions would have been greatly aided by a process whereby living materi...
This research demonstrates chemical reactions of RNA molecules that allow them to increase in length...
AbstractRNA strand exchange through phosphor-nucleotidyl transfer reactions is an intrinsic chemistr...
Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyz...
Understanding the mechanism of spontaneous formation of ribonucleotides under realistic prebiotic co...
AbstractWe have engineered a self-processing RNA, derived from the hairpin ribozyme that runs throug...
International audienceUnderstanding the mechanism of spontaneous formation of ribonucleotides under ...
An early stage of life likely used catalytic RNAs (ribozymes) to support self-replication and a meta...
The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme th...
The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as geno...