Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
- Nielsen, Jonas B
- Thorolfsdottir, Rosa B
- Fritsche, Lars G
- Zhou, Wei
- Skov, Morten W
- Graham, Sarah E
- Herron, Todd J
- McCarthy, Shane
- Schmidt, Ellen M
- Sveinbjornsson, Gardar
- Surakka, Ida
- Mathis, Michael R
- Yamazaki, Masatoshi
- Crawford, Ryan D
- Gabrielsen, Maiken E
- Skogholt, Anne Heidi
- Holmen, Oddgeir L
- Lin, Maoxuan
- Wolford, Brooke N
- Dey, Rounak
- Dalen, Håvard
- Sulem, Patrick
- Chung, Jonathan H
- Backman, Joshua D
- Arnar, David O
- Thorsteinsdottir, Unnur
- Baras, Aris
- O'Dushlaine, Colm
- Holst, Anders G
- Wen, Xiaoquan
- Hornsby, Whitney
- Dewey, Frederick E
- Boehnke, Michael
- Kheterpal, Sachin
- Mukherjee, Bhramar
- Lee, Seunggeun
- Kang, Hyun M
- Holm, Hilma
- Kitzman, Jacob
- Shavit, Jordan A
- Jalife, José
- Brummett, Chad M
- Teslovich, Tanya M
- Carey, David J
- Gudbjartsson, Daniel F
- Stefansson, Kari
- Abecasis, Gonçalo R
- Hveem, Kristian
- Willer, Cristen J
DOIAbstract
To access publisher's full text version of this article click on the hyperlink belowTo identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)Stiftelsen Kristian Gerhard Jebsen Faculty of Medicine and Health Sciences Norwegian University of Scie...
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