Diagnostic and therapeutic approaches to multiple myeloma patients - case report

Multipli mijelom je zloćudno bujanje plazma stanica koje stvaraju abnormalni imunoglobulin, zbog čega dolazi do monoklonske gamapatije, a karakterizira ju prisutnost M proteina u serumu i urinu. Elektroforeza serumskih proteina je jednostavan dijagnostički test koji se koristi za dokazivanje i kvantifikaciju monoklonske gamapatije, te ga je potrebno učiniti kao preliminarni test kod sumnje na multipli mijelom. U radu su kroz prikaz bolesnika ilustrirana ključna pitanja u skrbi o bolesnicima oboljelima od multiplog mijeloma, a opisana je relevantna patofiziologija, klinička slika, dijagnostički postupci, te liječenje oboljelih.Multiple myeloma is a neoplasm characterized by excessive proliferation of the plasma cells, secreting abnormal immunoglobulin causing monoclonal gammopathy and it is characterised by the presence of M protein in serum and urine. Electrophoresis of serum protein is an easy laboratory test which can be used for detection and quantification of monoclonal gammopathy and should be used as a preliminary test for detecting multiple myeloma. In this paper we described key issues in the care of patients with multiple myeloma. Using the case report, we showed the pathophysiology, clinical picture, diagnostic procedures and treatment of patients with multiple myeloma