Importance of investigation of bile salts and their derivatives as building blocks of supramolecular hosts for the purpose of treatment

Prikazan je niz fizikalno-kemijskih metoda i tehnika korištenih u ispitivanju modelnih žučnih sustava. Ispitano je međudjelovanje anionske, biološke površinski aktivne tvari, natrijevoga kolata i sintetskih jednolančanih i dvolančanih površinski aktivnih tvari, te natrijeva kolata i metalnih iona rastućega naboja. Sustavi omogućuju novi pogled na kompleksne postupke taloženja, vezikulacije i geliranja, te bolje razumijevanje procesa koji se odvijaju u živom organizmu. Utvrđena je zavisnost svojstava molekula žučnih soli i njihovih derivata o molekulskim međudjelovanjima, molekulskom pakiranju i svojstvima kristalnoga taloga, tako da se mogu koristiti kao supramolekulski receptori za različite vrste gostujućih molekula i iona, te u dizajnu budućih materijala. Takva istraživanja nalaze svoj značaj u fiziologiji (u dijagnozi ili razvoju novih farmakoloških pripravaka) ili patofiziologiji (u sprječavanju štetnih reakcija, kao npr. taloženja), ukazujući na usku povezanost medicine s biotehnologijom, organskom, makromolekulskom, anorganskom i fizikalnom kemijom.This article reports a variety of physico-chemical methods and techniques that have been used in the research of native, model bile systems. Interactions of the anionic biological surfactant, odium cholate and synthetic single- and double- chained surfactants, as well as sodium cholate and metal ions with increasing charges, were examined. These systems provide new insight into the complex processes of precipitation, vesiculation and gelation, and better understanding of those that take place in the living organism. The dependence of molecules of bile salts and their analogues on molecular interactions, molecular packing and properties of crystalline materials is established, so they can be utilized as supramolecular receptors for various types of guest molecules and ions, and for the design of novel materials. Such researches find their physiological (in diagnosis or developing new pharmacological applications) or pathophysiological relevance (in preventing harmful reactions, such as precipitation), and show close relationship between medicine and biotechnology, organic, macromolecular, inorganic and physical chemistry