Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse functional roles ranging from neurotransmission to acid-base balance, intracellular energy metabolism, and anabolic and catabolic reactions. In cancer cells and diabetes, dysregulation of AATs leads to metabolic reprogramming, which changes intracellular amino acid levels, contributing to the pathogenesis of cancer, obesity and diabetes. Indeed, the neutral amino acid transporters (NATs) SLC7A5/LAT1 and SLC1A5/ASCT2 are likely involved in several human malignancies. However, a clinical therapy that directly targets AATs has not yet been developed. The purpose of this review...
There is growing recognition that amino acid availability has profound effects on many aspects of ce...
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpress...
Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently ...
Amino acids perform a variety of functions in cells and organisms, particularly in the synthesis of ...
Amino acids are essential building blocks of all mammalian cells. In addition to their role in prote...
The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon th...
Administered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other d...
Amino acid transporters of the SLC6 family mediate the Na⁺-dependent uptake of neutral amino acids i...
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localiz...
The Solute Carrier 1A (SLC1A) family comprises a group of membrane proteins that act as dual-functio...
In cells and organelles transporters are responsible for translocation of amino acids, sugars and nu...
AbstractTumor cells have an increased demand for glucose and amino acids to support their rapid grow...
<p>The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but t...
Amino acid transporters are expressed in mammalian cells not only in the plasma membrane but also in...
Amino acid transporters are membrane transport proteins, most of which are members of the solute car...
There is growing recognition that amino acid availability has profound effects on many aspects of ce...
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpress...
Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently ...
Amino acids perform a variety of functions in cells and organisms, particularly in the synthesis of ...
Amino acids are essential building blocks of all mammalian cells. In addition to their role in prote...
The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon th...
Administered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other d...
Amino acid transporters of the SLC6 family mediate the Na⁺-dependent uptake of neutral amino acids i...
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localiz...
The Solute Carrier 1A (SLC1A) family comprises a group of membrane proteins that act as dual-functio...
In cells and organelles transporters are responsible for translocation of amino acids, sugars and nu...
AbstractTumor cells have an increased demand for glucose and amino acids to support their rapid grow...
<p>The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but t...
Amino acid transporters are expressed in mammalian cells not only in the plasma membrane but also in...
Amino acid transporters are membrane transport proteins, most of which are members of the solute car...
There is growing recognition that amino acid availability has profound effects on many aspects of ce...
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpress...
Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently ...