Long-term immune response to yellow fever vaccination in HIV-infected individuals depends on HIV-RNA suppression status: Implications for vaccination schedule.
- Veit, Olivia Stephanie
- Domingo, Cristina
- Niedrig, Matthias
- Staehelin, Cornelia
- Sonderegger, Beat
- Delphine, Héquet
- Stoeckle, Marcel
- Calmy, Alexandra
- Schiffer, Veronique
- Bernasconi, Enos
- Flury, Domenica
- Hatz, Christoph
- Zwahlen, Marcel
- Furrer, Hansjakob
DOIAbstract
Background In HIV-infected individuals the immune response over time to yellow fever vaccination (YFV) and the necessity for booster vaccination are not well understood. Methods We studied 247 participants of the Swiss HIV Cohort Study (SHCS) with a first YFV after HIV diagnosis and determined their immune responses at one, five, and ten years postvaccination (p.v.) by yellow fever plaque reduction neutralisation titres (PRNT) in stored blood samples. A PRNT of 1:≥10 was regarded as reactive and protective. Predictors of vaccination response were analysed with Poisson regression. Results At vaccination, 82% of the vaccinees were taking combination antiretroviral therapy (cART), 83% had suppressed HIV RNA levels (<400 copies/m...
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