A decade of HIV care in rural Tanzania: Trends in clinical outcomes and impact of clinic optimisation in an open, prospective cohort.
- Vanobberghen, Fiona
- Letang, Emilio
- Gamell, Anna
- Mnzava, Dorcas K
- Faini, Diana
- Luwanda, Lameck B
- Mapesi, Herry
- Mwamelo, Kim
- Sikalengo, George
- Tanner, Marcel
- Hatz, Christoph
- Furrer, Hansjakob
- Battegay, Manuel
- Glass, Tracy R
DOIAbstract
OBJECTIVES Our objectives were to describe trends in enrolment and clinical outcomes in the open, prospective Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) in the Morogoro region of southern Tanzania, and identify strengths and areas for improvement in the care of HIV-positive individuals in rural Tanzania. METHODS We included adults (≥15 years) and children (<15 years) enrolled in the cohort in 2005-2014. The cohort underwent significant changes from autumn 2012 to optimise care. We evaluated mortality and loss to follow-up (LTFU) using competing risks methods, ART usage, opportunistic infections (OI), co-infections and laboratory abnormalities. RESULTS Overall, 7010 adults and 680 children were enrolled; enrolment p...
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