We present results on the light, strange and charm nucleon scalar and tensor charges from lattice QCD, using simulations with Nf 1⁄4 2 flavors of twisted mass clover-improved fermions with a physical value of the pion mass. Both connected and disconnected contributions are included, enabling us to extract the isoscalar, strange and charm charges for the first time directly at the physical point. Furthermore, the renormalization is computed nonperturbatively for both isovector and isoscalar quantities. We investigate excited state effects by analyzing several sink-source time separations and by employing a set of methods to probe ground state dominance. Our final results for the scalar charges are guS = 5.20(42)(15)(12), gdS = 4.27(26)(15)(1...