The use of a mixture of somatic and culture filtrate antigens in the evaluation of the immune response to Paracoccidioides brasiliensis
- Silva, M. I. Correa da
- Carvalho, I. Maximo de
- Franco, T. N.
- Cunha, M. A.
- Chamma, L. G.
- Fogaca, J.
- Fecchio, Denise
- Franco, M.
Publication date
October 1991
DOI Publisher
Blackwell Science Journal
0268-1218Abstract
Three Paracoccidioides brasiliensis antigens, namely a culture filtrate preparation, a somatic antigen and a mixture of equal parts of the two, were tested by two serological techniques against sera from patients with paracoccidioidomycosis, and in an in vivo delayed hypersensitivity model in mice. The antigen mixture was more sensitive than the two individual antigens for the evaluation of humoral and cellular immune response to P. brasiliensis, both in man and in experimental animals
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