Influência da obesidade sobre o tecido ósseo de Rattus novergicus albinus idosos, submetidos à suspensão pela cauda e ao exercício resistido

In this study was evaluated the effects that obesity induced by sucrose intake provides in bone tissue of aged male Wistar rats in two opposite situations: in extreme inactivity, and performing strength exercises. Physical inactivity was induced by tail suspension, simulating situations of little or no load on the hindlimbs and the exercises were performed on adapted ladder. 54 male rats with 16 months old were studied. Upon completion 13 months old, 27 rats were randomly selected to receive sucrose-rich diet for 3 months. Analyzes were made: with densitometer to measure bone mineral content, bone mineral density and area in the femurs and tibias; Mechanical tests of compression of the femoral head, tibial compression and compression of the cortical bone and Immunohistochemical analysis with markings for OCN and TRAP. The results showed obese animals that performed exercises had significant improvement (p<0,05) in BMC of femurs, while non-obese animals that performed exercises showed improvement in BMC of femurs and tibias, ABMD of femurs and tibias, and the maximum allowed force of tibias. The suspended animals had a significant bone quality loss (p