GENOTOXIC AND MUTAGENIC EFFECTS OF DIFLUBENZURON, AN INSECT GROWTH REGULATOR, ON MICE
- Barros, Aline Lima de
- Souza, Vanessa Vilamaior de
- Navarro, Stephanie Dynczuki
- Oesterreich, Silvia Aparecida
- Oliveira, Rodrigo Juliano
- Leite Kassuya, Candida Aparecida
- Arena, Arielle Cristina
Publication date
September 2013
DOI Publisher
Taylor & Francis Inc Journal
1528-7394Abstract
This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. Mice were divided into five groups: group I: negative control; group II: positive control; group III: 0.3 mg/kg of DFB; group IV: 1 mg/kg of DFB; group V: 3 mg/kg DFB. Peripheral blood was collected for the comet assay and the micronucleus (MN) test. DFB increased incidence of comet formation at all doses tested. A rise in the frequency of MN in mouse peripheral blood was observed 24, 48, and 72 h postexposure at all doses tested. Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES
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