Add to ORKGLocal anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion c...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
BACKGROUND AND OBJECTIVES: In order to prolong the action and reduce systemic toxicity, formulations...
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pa...
Local anesthetics are substances able to induce pain relief by binding to the sodium channel of exci...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
Ropivacaine (RVC) is an enantiomerically pure local anesthetic (LA) largely used in surgical procedu...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
BACKGROUND: Bupivacaine (BVC) and ropivacaine (RVC) are local anesthetics widely used in surgical pr...
Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or e...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
Bupivacaine-induced side effects have led to the search for new local anesthetics (LA) with similar ...
Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or e...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
BACKGROUND AND OBJECTIVES: In order to prolong the action and reduce systemic toxicity, formulations...
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pa...
Local anesthetics are substances able to induce pain relief by binding to the sodium channel of exci...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
Ropivacaine (RVC) is an enantiomerically pure local anesthetic (LA) largely used in surgical procedu...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
BACKGROUND: Bupivacaine (BVC) and ropivacaine (RVC) are local anesthetics widely used in surgical pr...
Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or e...
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
Bupivacaine-induced side effects have led to the search for new local anesthetics (LA) with similar ...
Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or e...
Local anesthetics are able to induce pain relief by binding to the sodium channel of excitable membr...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
BACKGROUND AND OBJECTIVES: In order to prolong the action and reduce systemic toxicity, formulations...