The computational effort of 3D image reconstruction in Computed Tomography (CT) has required special purpose hardware for a long time. Systems such as custom-built FPGA- systems and GPUs are still widely-used today, in particular in interventional settings, where radiologists require a hard time constraint for reconstruction. However, recently is has been shown that today even commodity CPUs are capable of performing the reconstruction within the imposed time-constraint. In this thesis, we examine the Intel Many Integrated Cores (MIC) architecture for its suit- ability to run the Feldkamp-Davis-Kress (FDK) algorithm—the most commonly used algo- rithm to perform the 3D image reconstruction in cone-beam computed tomography. In com- parison t...