IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced asthma in particular. Here we found an inverse correlation between T-bet and Il-6 mRNA expression in asthmatic children. Moreover, experimental subcutaneous immunotherapy (SIT) in T-bet(−/−) mice inhibited IL-6, IL-21R and lung TH17 cells in a setting of asthma. Finally, local delivery of an anti-IL-6R antibody in T-bet(−/−) mice resulted in the resolution of this allergic trait. Noteworthy, BATF, crucial for the immunoglobulin-class-switch and TH2,TH17 development, was found down-regulated ...
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in aller...
Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the...
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. ...
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting th...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
© 2015 American Academy of Allergy, Asthma & Immunology. Background A variant in the IL-6 receptor (...
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly u...
BACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly u...
We previously reported high levels of the soluble form of the IL-6R (sIL-6R) in the airways of asthm...
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in aller...
Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the...
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. ...
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting th...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 rece...
© 2015 American Academy of Allergy, Asthma & Immunology. Background A variant in the IL-6 receptor (...
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly u...
BACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environ...
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly u...
We previously reported high levels of the soluble form of the IL-6R (sIL-6R) in the airways of asthm...
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in aller...
Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the...
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. ...