Low magnesium in food is an abettor of calcium and magnesium accumulation in renal tissue, and dyslipidemia? Observations in men with idiopathic recurrent calcium urolithiasis responding to a low magnesium containing test meal with different degree of unrecovered magnesium in urine, and male rats fed a magnesium-deficient diet. With a re-appraisal of stone pathophysiology

Background: The role of Mg in pathophysiology of IRCU is incompletely understood and would benefit from animal models. Aims: To elucidate whether 1) Mg nutrition in IRCU impacts on Minerals and lipids in blood, minerals in urine, 2) dietary Mg deficiency of rats can serve as model for renal Ca and Mg accumulation. Procedures: 1. Adult male patients (clinical trial 1; n = 88) underwent a standardized laboratory program (urine and blood collections, intake of a TM with low Mg (type 1); from Mg retention, viz. Mg not appearing in urine, and stratification Mg retention ≥50% (H) or