Background Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication. CypA interacts with the virus proteins Capsid (CA) and Vpr, however, the mechanism through which CypA influences HIV-1 infectivity still remains unclear. Results Here the interaction of full-length HIV-1 Vpr with the host cellular factor CypA has been characterized and quantified by surface plasmon resonance spectroscopy. A C-terminal region of Vpr, comprising the 16 residues 75GCRHSRIGVTRQRRAR90, with high binding affinity for CypA has been identified. This region of Vpr does not contain any proline residues but binds much more strongly to CypA than...
BACKGROUND: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, catalyzes ...
AbstractCyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It ...
AbstractThe cellular protein cyclophilin A (CypA) is packaged into human immunodeficiency virus type...
Abstract Background Cyclophilin A (CypA) represents a potential key molecule in future antiretrovira...
Background: Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therap...
Publisher's PDFThe host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid an...
Background: Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhi...
AbstractBackground: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, ca...
A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclo...
Abstract Background Efficient HIV-1 replication depends on interaction of the viral capsid with the ...
<div><p>The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and reg...
AbstractCyclophilin A (Cyp A) binds the human immunodeficiency virus type 1 (HIV-1) capsid (CA) prot...
The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and regulates i...
AbstractThe HIV-1 capsid protein forms the conical core structure at the center of the mature virion...
Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for r...
BACKGROUND: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, catalyzes ...
AbstractCyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It ...
AbstractThe cellular protein cyclophilin A (CypA) is packaged into human immunodeficiency virus type...
Abstract Background Cyclophilin A (CypA) represents a potential key molecule in future antiretrovira...
Background: Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therap...
Publisher's PDFThe host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid an...
Background: Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhi...
AbstractBackground: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, ca...
A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclo...
Abstract Background Efficient HIV-1 replication depends on interaction of the viral capsid with the ...
<div><p>The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and reg...
AbstractCyclophilin A (Cyp A) binds the human immunodeficiency virus type 1 (HIV-1) capsid (CA) prot...
The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and regulates i...
AbstractThe HIV-1 capsid protein forms the conical core structure at the center of the mature virion...
Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for r...
BACKGROUND: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, catalyzes ...
AbstractCyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It ...
AbstractThe cellular protein cyclophilin A (CypA) is packaged into human immunodeficiency virus type...