We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3) M) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) and lung mast cells but not induced by ionophore A23197. The potentiation caused by adenosine (10(-4) M) was maximum after 1-3 min of preincubation and is probably an extracellular effect since it was not avoided by dipyridamol (3 x 10(-7)-10(-6) M) that inhibit the uptake of adenosine. Similar potentiation was also produced by the adenosine mimetic 2-chloroadenosine (10(-5) M) and both effects were inhibited by 8-phenyltheophy...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Procedures for the local application of chemical agents to individual rat peritoneal mast cells are ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
In anaesthetized guinea pigs, adenosine enhances the histamine-induced bronchospasm by means of a me...
Immunological activation of human basophils was associated with a transient monophasic rise in the c...
1 Adenosine and its metabolically stable analogue N.etbyl-carboxamidoadenosine (NECA) enhance histam...
The modulatory effects of adenosine and selected derivatives were examined on antigen and arachidoni...
Adenosine is known to attenuate the positive inotropic and chronotropic effects ofnorepinephnne and ...
Mast cells are pivotal effector cells in the pathogenesis of allergic and inflammatory diseases. Act...
Exogenous ATP has long been known to induce the exocytotic release of histamine from rat peritoneal ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Procedures for the local application of chemical agents to individual rat peritoneal mast cells are ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
Effect of adenosine, adenosine analogs and methylxanthines was studied on histamine release induced ...
In anaesthetized guinea pigs, adenosine enhances the histamine-induced bronchospasm by means of a me...
Immunological activation of human basophils was associated with a transient monophasic rise in the c...
1 Adenosine and its metabolically stable analogue N.etbyl-carboxamidoadenosine (NECA) enhance histam...
The modulatory effects of adenosine and selected derivatives were examined on antigen and arachidoni...
Adenosine is known to attenuate the positive inotropic and chronotropic effects ofnorepinephnne and ...
Mast cells are pivotal effector cells in the pathogenesis of allergic and inflammatory diseases. Act...
Exogenous ATP has long been known to induce the exocytotic release of histamine from rat peritoneal ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Procedures for the local application of chemical agents to individual rat peritoneal mast cells are ...