Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)
- Silva, Geraldo H.
- Oliveira, Camila M. de
- Teles, Helder L.
- Bolzani, Vanderlan da Silva
- Araújo, Angela Regina
- Pfenning, Ludwig H.
- Young, Maria Claudia M.
- Costa-Neto, Claudio M.
- Haddad, Renato
- Eberlin, Marcos N.
DOIAbstract
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfei...
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